监管涟漪。
Regulatory ripples.
机构信息
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
出版信息
Nat Immunol. 2010 Dec;11(12):1077-8. doi: 10.1038/ni1210-1077.
Abstract
Regulatory T cells come in many different forms depending on their mode of action or developmental origin. Data now show that interleukin 35, an immunomodulatory cytokine secreted by regulatory T cells, and interleukin 10 induce so-called 'iTR35 cells', which may have an important role in the phenomenon of infectious tolerance.
摘要
调节性 T 细胞有许多不同的形式，这取决于它们的作用模式或发育起源。现在的数据表明，调节性 T 细胞分泌的免疫调节细胞因子白细胞介素 35 和白细胞介素 10 诱导所谓的“iTR35 细胞”，这在感染性耐受现象中可能具有重要作用。
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本文引用的文献
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IL-35-mediated induction of a potent regulatory T cell population.IL-35 介导诱导产生强效调节性 T 细胞群体。
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Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC.人鼻病毒通过诱导树突状细胞上的 B7-H1（CD274）和唾液酸黏附素（CD169）诱导产生 IL-35 的 Treg。
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Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection.致死性感染期间Foxp3 +调节性T细胞数量减少及效应细胞表型的获得。
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Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses.调节性T细胞抑制程序借助转录因子IRF4来控制辅助性T细胞2型（TH2）反应。
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Human CD4+ CD25+ Foxp3+ regulatory T cells do not constitutively express IL-35.人类CD4+ CD25+ Foxp3+调节性T细胞并非组成性表达IL-35。
J Immunol. 2008 Nov 15;181(10):6898-905. doi: 10.4049/jimmunol.181.10.6898.
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CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner.CD4+ FoxP3+ 调节性T细胞以转化生长因子-β依赖的方式赋予感染性耐受。
J Exp Med. 2008 Sep 1;205(9):1975-81. doi: 10.1084/jem.20080308. Epub 2008 Aug 18.
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The inhibitory cytokine IL-35 contributes to regulatory T-cell function.抑制性细胞因子IL-35有助于调节性T细胞的功能。
Nature. 2007 Nov 22;450(7169):566-9. doi: 10.1038/nature06306.
8
IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells.白细胞介素-35是一种新型细胞因子，通过扩增调节性T细胞和抑制辅助性T细胞17发挥抗胶原诱导性关节炎的治疗作用。
Eur J Immunol. 2007 Nov;37(11):3021-9. doi: 10.1002/eji.200737810.
9
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid.小肠固有层树突状细胞通过视黄酸促进Foxp3调节性T细胞的从头生成。
J Exp Med. 2007 Aug 6;204(8):1775-85. doi: 10.1084/jem.20070602. Epub 2007 Jul 9.
10
Infectious tolerance and the long-term acceptance of transplanted tissue.感染性耐受与移植组织的长期接受
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