Division of Hematology, Marmara University School of Medicine, Istanbul, Turkey.
Int J Hematol. 2010 Dec;92(5):757-61. doi: 10.1007/s12185-010-0715-5. Epub 2010 Nov 16.
Precursor B cell lymphoblastic lymphoma (B-LBL) is quite uncommon and it usually manifests as an extranodal disease. Although B-LBL may present with bone involvement, it is a very rare manifestation of B-LBL as a primary solitary bone tumor. Here, we report a case of precursor B-LBL presenting with solitary bone tumor and a review of a total of seven adult patients reported previously in the literature. We described demographic and clinical characteristics of these patients with unique presentation and discussed treatment options. Unlike previous reports except one case, our patient underwent allogeneic stem cell transplantation (allo-SCT) due to refractory disease. She is alive without evidence of disease by the post-transplant 12th month. B-LBL has an aggressive clinical course in adult patients and allo-SCT may be the best treatment option.
前体 B 细胞淋巴母细胞淋巴瘤（B-LBL）较为罕见，通常表现为结外疾病。虽然 B-LBL 可能伴有骨累及，但作为原发性孤立性骨肿瘤的表现非常罕见。在此，我们报告一例表现为孤立性骨肿瘤的前体 B-LBL，并对文献中总共报道的 7 例成人患者进行了回顾。我们描述了这些具有独特表现的患者的人口统计学和临床特征，并讨论了治疗选择。与除 1 例外的以往报告不同，我们的患者因疾病难治而接受了异基因造血干细胞移植（allo-SCT）。在移植后第 12 个月，她无疾病证据，仍存活。B-LBL 在成人患者中具有侵袭性的临床病程，allo-SCT 可能是最佳治疗选择。
