Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany.
Eur J Immunol. 2010 Dec;40(12):3450-7. doi: 10.1002/eji.201040743.
Trogocytosis describes the transfer of surface determinants between immune cells and has been implicated in immune regulation. Most findings are based on in vitro studies since in vivo trogocytosis of immune cells is difficult to detect under physiological conditions. We used low frequencies of memory P14 T cells to demonstrate that T cells perform trogocytosis in vivo if in contact with APC pulsed with GP33-peptide or expressing the antigen endogenously. Furthermore, in vivo trogocytosis of T cells is demonstrated during infections with lymphocytic choriomeningitis virus and vaccinia virus. Trogocytosis-positive T cells revealed higher expression of activation marker and cytokines, showing a more activated phenotype compared to trogocytosis-negative T cells.
细胞融合作用描述了免疫细胞之间表面决定因素的转移，并与免疫调节有关。由于在生理条件下难以检测到免疫细胞的体内细胞融合作用，因此大多数发现都是基于体外研究。我们使用低频率的记忆 P14 T 细胞证明，如果与用 GP33 肽脉冲或内源性表达抗原的 APC 接触，T 细胞会在体内进行细胞融合作用。此外，在淋巴细胞性脉络丛脑膜炎病毒和牛痘病毒感染期间也证明了 T 细胞的体内细胞融合作用。与细胞融合作用阴性的 T 细胞相比，细胞融合作用阳性的 T 细胞显示出更高的激活标志物和细胞因子表达，表现出更活跃的表型。
