Department of Microbiology and Immunology, University of Michigan Medical School, 6606 Med Sci II, 1150 West Medical Center Drive, Ann Arbor, MI, 48109-5620, USA.
Cell Commun Signal. 2021 Sep 9;19(1):92. doi: 10.1186/s12964-021-00766-3.
Once thought of primarily as a means to neutralize pathogens or to facilitate feeding, endocytosis is now known to regulate a wide range of eukaryotic cell processes. Among these are regulation of signal transduction, mitosis, lipid homeostasis, and directed migration, among others. Less well-appreciated are the roles various forms of endocytosis plays in regulating αβ and, especially, γδ T cell functions, such as T cell receptor signaling, antigen discovery by trogocytosis, and activated cell growth. Herein we examine the contribution of both clathrin-mediated and clathrin-independent mechanisms of endocytosis to T cell biology. Video Abstract.
最初，胞吞作用被认为主要是为了中和病原体或促进进食，但现在已知它可以调节真核细胞的广泛过程。其中包括信号转导、有丝分裂、脂质动态平衡和定向迁移等。不太为人所知的是，各种形式的胞吞作用在调节αβ和γδ T 细胞功能方面所起的作用，例如 T 细胞受体信号转导、通过 trogocytosis 发现抗原和激活细胞生长。本文我们研究了网格蛋白介导和网格蛋白非依赖的胞吞作用机制对 T 细胞生物学的贡献。视频摘要。
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