University of California, San Francisco, 94143, USA.
Arthritis Care Res (Hoboken). 2011 Mar;63(3):358-65. doi: 10.1002/acr.20402. Epub 2010 Nov 15.
Disease activity and medication use can complicate pregnancies in patients with systemic lupus erythematosus (SLE). We therefore examined contraceptive counseling and use among women in the University of California, San Francisco Lupus Outcomes Study.
In 2008, we queried participants regarding their pregnancy intentions, contraceptive use, and receipt of contraceptive counseling. Premenopausal women age <45 years who were sexually active with men were considered at risk of pregnancy. We compared self-reported rates of contraceptive counseling and use stratified by treatment with teratogenic medications and by history of thrombosis or antiphospholipid antibodies (aPL), using chi-square tests. We used logistic regression models to examine predictors of contraceptive counseling and use.
Among 206 women, 86 were at risk for unplanned pregnancy. Most (59%) had not received contraceptive counseling in the last year, 22% reported inconsistent contraceptive use, and 53% depended solely on barrier methods. Intrauterine device contraceptives (IUDs) were used by 13%. Women using potentially teratogenic medications were no more likely to have received contraceptive counseling, to have used contraception consistently, or to have used more effective contraceptives. A history of thrombosis or aPL did not account for low rates of hormonal methods. Four women with a history of thrombosis or aPL were using estrogen-containing contraceptives.
Most women at risk for unplanned pregnancy reported no contraceptive counseling in the past year, despite common use of potentially teratogenic medications. Many relied upon contraceptive methods with high failure rates; few used IUDs. Some were inappropriately using estrogen-containing contraceptives. These findings suggest the need to improve the provision of contraceptive services to women with SLE.
疾病活动和药物使用可能会使系统性红斑狼疮(SLE)患者的妊娠复杂化。因此,我们检查了加利福尼亚大学旧金山狼疮结局研究中女性的避孕咨询和使用情况。
2008 年,我们调查了参与者的妊娠意愿、避孕措施使用情况以及避孕咨询情况。有生育能力的性活跃女性年龄<45 岁,有怀孕风险。我们使用卡方检验比较了接受致畸药物治疗和有血栓或抗磷脂抗体(aPL)病史的患者在接受避孕咨询和使用避孕措施方面的自我报告率。我们使用逻辑回归模型检查了避孕咨询和使用的预测因素。
在 206 名女性中,有 86 人有意外怀孕的风险。大多数(59%)在过去一年中未接受避孕咨询,22%报告避孕措施使用不一致,53%仅依赖于屏障方法。宫内节育器(IUD)的使用率为 13%。使用潜在致畸药物的女性不太可能接受避孕咨询,也不太可能持续使用避孕措施,或使用更有效的避孕措施。血栓或 aPL 病史并不能解释激素避孕方法使用率低的原因。有血栓或 aPL 病史的 4 名女性正在使用含有雌激素的避孕药。
尽管普遍使用潜在致畸药物,但大多数有意外怀孕风险的女性在过去一年中未接受避孕咨询。许多人依赖于避孕失败率高的避孕方法;很少使用 IUD。一些人不适当地使用含有雌激素的避孕药。这些发现表明需要改善对 SLE 女性提供避孕服务。