Cedars M I, Surey E, Hamilton F, Lapolt P, Meldrum D R
University of California, Los Angeles.
Fertil Steril. 1990 Apr;53(4):627-31. doi: 10.1016/s0015-0282(16)53454-2.
Levels of immunoreactive luteinizing hormone (LH), bioactive LH, and testosterone (T) were determined in 52 women receiving human menopausal gonadotropins (hMG). In 26 women receiving leuprolide acetate (LA) preceding hMG, there was a significant suppression of immunoreactive LH and bioactive LH. The characteristic increase in serum levels of bioactive LH and T were absent. Follicular fluid estradiol and T concentrations, and serum progesterone were not different. The lower circulating levels of T may reflect reduced LH-stimulated androgen accumulation in smaller nonaspirated follicles and may account for the enhanced follicle recruitment observed during LA. The lack of premature luteinization despite marked rises of bioactive LH in the absence of LA is consistent with normal events during the menstrual cycle and was due to the early termination of hMG stimulation.
对52名接受人绝经期促性腺激素（hMG）治疗的女性测定了免疫反应性促黄体生成素（LH）、生物活性LH和睾酮（T）的水平。在26名在hMG治疗前接受醋酸亮丙瑞林（LA）治疗的女性中，免疫反应性LH和生物活性LH受到显著抑制。生物活性LH和T的血清水平没有出现特征性升高。卵泡液雌二醇和T浓度以及血清孕酮没有差异。T的循环水平较低可能反映了较小的未抽吸卵泡中LH刺激的雄激素积累减少，这可能是LA治疗期间观察到卵泡募集增强的原因。在没有LA的情况下，尽管生物活性LH显著升高，但未发生过早黄素化，这与月经周期中的正常情况一致，是由于hMG刺激提前终止所致。
