Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Ann Rheum Dis. 2011 Feb;70(2):334-6. doi: 10.1136/ard.2010.133603. Epub 2010 Nov 15.
To determine the impact of limitations in daily activities and pain on quality of life (QoL) in patients with osteoarthritis (OA) visiting a rheumatologist.
Patients diagnosed by the rheumatologist with primary hand, knee or hip OA were consecutively included from August 2005 to April 2009. QoL was assessed by Short Form-36, with the physical component summary score (PCS), calculated using data from a norm-based population. Self-reported pain and function in patients with hand OA was assessed by the Australian/Canadian OA hand index (AUSCAN) pain (range 0-20) and AUSCAN function (range 0-36). Linear regression analyses were performed to investigate associations between PCS and demographic characteristics, and between PCS and pain and function in patients with OA.
Hand OA was diagnosed in 95% of 460 included patients (89% women, mean age 61 years). PCS was lowered in patients with OA. Patients with hand OA reported a considerable amount of pain (mean 9.5 (SD 4.3)) and disability (mean 16.5 (SD 8.6)). AUSCAN function was associated with PCS (adjusted β=-0.3, 95% CI -0.4 to -0.2), but AUSCAN pain was not.
Hand OA was the most common OA subtype in secondary care. Health-related QoL is decreased in patients with OA and is associated with limitations in daily activities.
确定日常活动受限和疼痛对看风湿科的骨关节炎（OA）患者生活质量（QoL）的影响。
2005 年 8 月至 2009 年 4 月，连续纳入由风湿病学家诊断为原发性手部、膝部或髋部 OA 的患者。采用基于常模人群的短表 36 评估 QoL，计算身体成分综合评分（PCS）。手部 OA 患者的自我报告疼痛和功能通过澳大利亚/加拿大手部 OA 指数（AUSCAN）疼痛（范围 0-20）和 AUSCAN 功能（范围 0-36）进行评估。进行线性回归分析以调查 PCS 与人口统计学特征之间的关联，以及 PCS 与 OA 患者疼痛和功能之间的关联。
460 例纳入患者中 95%（89%为女性，平均年龄 61 岁）诊断为手部 OA。OA 患者的 PCS 降低。手部 OA 患者报告有相当程度的疼痛（平均 9.5（SD 4.3））和残疾（平均 16.5（SD 8.6））。AUSCAN 功能与 PCS 相关（调整后的β=-0.3，95%CI -0.4 至 -0.2），但 AUSCAN 疼痛与之无关。
手部 OA 是二级保健中最常见的 OA 亚型。OA 患者的健康相关 QoL 下降，与日常活动受限有关。
