The Department of Internal Medicine, Sakura Medical Center, School of Medicine, Toho University, Sakura-City, Chiba, Japan.
J Atheroscler Thromb. 2011;18(2):148-56. doi: 10.5551/jat.6197. Epub 2010 Nov 11.
Recent clinical studies have reported that low lipoprotein lipase mass in preheparin serum (s-LpL) and hypoadiponectinemia are important risk factors for acute myocardial infarction (AMI). The aim of this study was to elucidate the relationship between low s-LpL and hypoadiponectinemia, both of which are risk factors for AMI.
One hundred and thirty-seven male patients with AMI and fifty-three males with normal coronary arteries (NCA) were enrolled in the study. Coronary risk factors, including s-LpL and serum total adiponectin concentrations (t-adiponectin), were compared.
Both s-LpL and t-adiponectin were significantly lower in patients with AMI than in subjects with NCA (s-LpL, NCA: 48.1±11.0 ng/mL, AMI: 38.9±11.1 ng/mL, p< 0.01; t-adiponectin, NCA: 7.7±2.9 µg/mL, AMI: 6.1±3.3 µg/mL, p< 0.01). In AMI patients, there was a significant positive correlation between s-LpL and t-adiponectin (r=0.46, p< 0.01). Furthermore, multivariate analysis indicated that both s-LpL and t-adiponectin were independent variables for AMI (s-LpL: p< 0.05, t-adiponectin: p< 0.05).
These results indicate that although low s-LpL and hypoadiponectinemia are associated with each other, they are independent risk factors for AMI.
最近的临床研究报告称，肝素前血清中脂蛋白脂酶质量低（s-LpL）和脂联素水平降低是急性心肌梗死（AMI）的重要危险因素。本研究旨在阐明低 s-LpL 和低脂联素血症（均为 AMI 的危险因素）之间的关系。
本研究纳入了 137 名男性 AMI 患者和 53 名冠状动脉正常男性（NCA）。比较了包括 s-LpL 和血清总脂联素浓度（t-脂联素）在内的冠心病危险因素。
AMI 患者的 s-LpL 和 t-脂联素均显著低于 NCA 患者（s-LpL，NCA：48.1±11.0 ng/mL，AMI：38.9±11.1 ng/mL，p<0.01；t-脂联素，NCA：7.7±2.9 µg/mL，AMI：6.1±3.3 µg/mL，p<0.01）。在 AMI 患者中，s-LpL 与 t-脂联素呈显著正相关（r=0.46，p<0.01）。此外，多元分析表明，s-LpL 和 t-脂联素均为 AMI 的独立变量（s-LpL：p<0.05，t-脂联素：p<0.05）。
这些结果表明，尽管低 s-LpL 和低脂联素血症相互关联，但它们是 AMI 的独立危险因素。
