Hitsumoto Takashi, Yoshinaga Kunio, Aoyagi Kaneyuki, Sakurai Takeshi, Kanai Masahito, Uchi Takashi, Noike Hirofumi, Ohsawa Hidefumi, Watanabe Hitoshi, Shirai Kohji
Cardiovascular Center, Sakura Hospital, School of Medicine, Toho University, Sakura-City, Chiba, Japan.
J Atheroscler Thromb. 2002;9(4):163-9. doi: 10.5551/jat.9.163.
A sensitive immunoassay system using a specific monoclonal antibody against lipoprotein lipase (LPL) recently demonstrated the presence of an LPL mass in preheparin serum. We reported that a preheparin serum LPL mass (pre-LPL mass) reflected the level of functioning LPL activity in the whole body and could be deeply involved in the progression of coronary atherosclerosis of stable organic angina pectoris. We examined the relation between the pre-LPL mass and acute myocardial infarction (AMI). We studied 44 males with AMI (AMI group) and 16 males with a normal coronary artery (NCA group), and measured the pre-LPL mass by enzyme-linked immunosorbent assay. Coronary risk factors including the pre-LPL mass were compared between the two groups and multiple regression analysis was performed for AMI. There were no significant differences in the lipid data, but the pre-LPL mass level was significantly low in the AMI group (52 +/- 16 vs 41 +/- 14 ng/ml, p = 0.01), and a low pre-LPL mass concentration was observed in the small sized LDL group and/or the Midband positive group. Multiple regression analysis revealed that a low pre-LPL mass and hypertriglyceridemia were independent risk factors for AMI (t value = 2.1, 2.4). The result indicates that a low pre-LPL mass may be an important risk factor for AMI and stable organic angina pectoris.
一种使用抗脂蛋白脂肪酶（LPL）特异性单克隆抗体的灵敏免疫测定系统最近证实了肝素前血清中存在LPL物质。我们报告称，肝素前血清LPL物质（前LPL物质）反映了全身功能性LPL活性水平，并且可能与稳定型劳力性心绞痛冠状动脉粥样硬化的进展密切相关。我们研究了前LPL物质与急性心肌梗死（AMI）之间的关系。我们对44例男性AMI患者（AMI组）和16例冠状动脉正常的男性（NCA组）进行了研究，并通过酶联免疫吸附测定法测量了前LPL物质。比较了两组包括前LPL物质在内的冠状动脉危险因素，并对AMI进行了多元回归分析。两组脂质数据无显著差异，但AMI组的前LPL物质水平显著较低（52±16 vs 41±14 ng/ml，p = 0.01），并且在小颗粒LDL组和/或中带阳性组中观察到较低的前LPL物质浓度。多元回归分析显示，低前LPL物质和高甘油三酯血症是AMI的独立危险因素（t值 = 2.1，2.4）。结果表明，低前LPL物质可能是AMI和稳定型劳力性心绞痛的重要危险因素。
