甲硝唑诱发脑脓肿患者发生脑病。
Metronidazole induced encephalopathy in a patient with brain abscess.
作者信息
Bahn Yoochang, Kim Eunyoung, Park Chongoon, Park Hyung-Chun
机构信息
Department of Neurosurgery, Inha University Hospital, Inha University College of Medicine, Incheon, Korea.
出版信息
J Korean Neurosurg Soc. 2010 Sep;48(3):301-4. doi: 10.3340/jkns.2010.48.3.301. Epub 2010 Sep 30.
Abstract
Metronidazole is commonly used for brain abscess but is not well known for its neurotoxic complications. Metronidazole-induced encephalopathy (MIEP) is toxic encephalopathy associated with the use of metronidazole. We experienced a case of brain abscess which developed reversible severe MIEP during treatment period. Although MIEP occurs in typical locations, it is not easy to differentiate from other conditions such as cerebral infarction, demyelinating diseases and metabolic diseases. Neurosurgeons should be aware that severe MIEP can occur during the use of metronidazole though it is not common.
摘要
甲硝唑常用于治疗脑脓肿，但其神经毒性并发症并不为人熟知。甲硝唑诱发的脑病（MIEP）是与使用甲硝唑相关的中毒性脑病。我们遇到一例脑脓肿患者，在治疗期间发生了可逆性严重MIEP。尽管MIEP发生在典型部位，但与脑梗死、脱髓鞘疾病和代谢性疾病等其他病症鉴别并不容易。神经外科医生应意识到，尽管严重MIEP并不常见，但在使用甲硝唑期间仍可能发生。
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