Institute of Work and Health, Lausanne, Switzerland.
Int Arch Occup Environ Health. 2011 Apr;84(4):371-4. doi: 10.1007/s00420-010-0596-1. Epub 2010 Nov 17.
Recent work practices in the conservation and restoration involve the use of cyclododecane (CDD, CAS 294-62-2) to protect fragile artifacts during their handling or transportation. Little is known about its toxicity, and no previous exposure has been reported. A short field investigation was conducted to characterize the exposure conditions to both CDD vapors and aerosols.
Measurements were conducted in the laboratory of conservation and restoration of the archeological service in Bern (Switzerland). Three indoor and four outdoor typical work situations, either during brush or spray gun applications, were investigated. Measurements were performed on charcoal adsorbent tube and analyzed by a gas chromatograph equipped with a flame ionization detector.
Measurements have been conducted during both brush and spray gun applications. Indoor exposures were of 0.75-15.5 mg/m(3), while outdoors exposures were 19.5-53.9 mg/m(3). Exposures appear to be extremely localized due to both physicochemical properties and application methods of the CDD. Vapor exposure increases dramatically with the confinement of the workplace.
Preventive measures should be undertaken to limit as much as possible these exposures. Field work in confined areas (ditches, underground) is of particular concern. CDD-coated artifacts or materials should be stored in ventilated areas to avoid delayed exposures.
最近在保护和修复文物的工作实践中，涉及到使用环十二烷（CDD，CAS 294-62-2）来保护在搬运或运输过程中脆弱的文物。目前对其毒性知之甚少，也没有报告过以前的接触情况。进行了一项简短的现场调查，以描述暴露于 CDD 蒸气和气溶胶的条件。
在瑞士伯尔尼的考古服务保护和修复实验室进行了测量。调查了三种室内和四种室外典型工作情况，包括刷子或喷枪应用时的情况。在活性炭吸附管上进行测量，并通过配备火焰电离检测器的气相色谱仪进行分析。
在刷子和喷枪应用期间都进行了测量。室内暴露浓度为 0.75-15.5mg/m3，而室外暴露浓度为 19.5-53.9mg/m3。由于 CDD 的物理化学性质和应用方法，暴露似乎非常局限。由于工作场所的封闭，蒸气暴露会急剧增加。
应采取预防措施，尽可能限制这些暴露。在封闭区域（沟渠、地下）进行野外工作尤其令人关注。应将涂有 CDD 的文物或材料储存在通风良好的区域，以避免延迟暴露。
