Department of Child Psychiatry, University of Turku, Varia, 3rd floor, Itäinen Pitkäkatu 1, 20014 Turku, Finland.
J Autism Dev Disord. 2011 Aug;41(8):1090-6. doi: 10.1007/s10803-010-1132-6.
This article presents an overview of the Finnish Prenatal Study of Autism and Autism Spectrum Disorders (FIPS-A), a new study designed to examine the relationship between prenatal serologic factors, mediating and moderating developmental antecedents, and risk of autism spectrum disorders (ASD). The FIPS-A is based on register linkages between births from 1987 to 2005 ascertained from the Finnish Medical Birth Register (FMBR) and other national registers on treatment for this group of disorders. All subjects were members of the Finnish Maternity Cohort (FMC), which consists of virtually all births in Finland from 1983 to the present, and which includes archived maternal serum samples. This study also capitalizes on other registry information, such as systematically collected data on pregnancy, prenatal and neonatal complications and manual data collection from well-child clinics providing developmental data from birth to the age of 7 years. In this paper, we describe the methods used in the FIPS-A study, including a description of the national registers, available data and case ascertainment procedures. Finally, we discuss implications of the data for future work on uncovering putative aetiologies of ASD and key strengths and limitations of the design.
本文概述了芬兰自闭症和自闭症谱系障碍产前研究（FIPS-A），这是一项旨在研究产前血清因素、中介和调节发育前因与自闭症谱系障碍（ASD）风险之间关系的新研究。FIPS-A 基于从芬兰医疗出生登记处（FMBR）和其他国家登记处获得的 1987 年至 2005 年出生的登记链接，这些出生均被确定为该疾病组的治疗。所有研究对象均为芬兰母婴队列（FMC）的成员，该队列由芬兰 1983 年至今的几乎所有出生组成，其中包括存档的母亲血清样本。该研究还利用了其他登记信息，例如系统收集的妊娠、产前和新生儿并发症数据以及从为儿童提供从出生到 7 岁发育数据的诊所收集的手工数据。在本文中，我们描述了 FIPS-A 研究中使用的方法，包括对国家登记处、可用数据和病例确定程序的描述。最后，我们讨论了这些数据对未来揭示 ASD 潜在病因以及设计的主要优势和局限性的影响。
