Atladóttir Hjördís Osk, Parner Erik T, Schendel Diana, Dalsgaard Søren, Thomsen Per Hove, Thorsen Poul
North Atlantic Neuro-Epidemiology Alliances at Department of Epidemiology, Institute of Public Health, University of Aarhus, Aarhus, Denmark.
Arch Pediatr Adolesc Med. 2007 Feb;161(2):193-8. doi: 10.1001/archpedi.161.2.193.
To examine trends in autism (autism spectrum disorder and childhood autism) in the context of 3 additional childhood neuropsychiatric disorders: hyperkinetic disorder, Tourette syndrome, and obsessive-compulsive disorder.
Population-based cohort study.
Children were identified in the Danish Medical Birth Registry. Relevant outcomes were obtained via linkage with the Danish National Psychiatric Register, which included reported diagnoses through 2004 by psychiatrists using diagnostic criteria from the International Statistical Classification of Diseases, 10th Revision.
All children born in Denmark from 1990 through 1999, a total of 669 995 children.
Cumulative incidence proportion by age, stratified by year of birth, for each disorder.
Statistically significant increases were found in cumulative incidence across specific birth years for autism spectrum disorder, childhood autism, hyperkinetic disorder, and Tourette syndrome. No significant change in cumulative incidence was observed for obsessive-compulsive disorder.
Recent increases in reported autism diagnoses might not be unique among childhood neuropsychiatric disorders and might be part of a more widespread epidemiologic phenomenon. The reasons for the observed common pattern of change in reported cumulative incidence could not be determined in this study, but the data underscore the growing awareness of and demand for services for children with neurodevelopmental disorders in general.
在另外三种儿童神经精神疾病（多动障碍、抽动秽语综合征和强迫症）的背景下，研究自闭症（自闭症谱系障碍和儿童自闭症）的发病趋势。
基于人群的队列研究。
从丹麦医学出生登记处识别儿童。通过与丹麦国家精神病学登记处建立联系获取相关结果，该登记处包括精神科医生根据《国际疾病分类》第10版诊断标准截至2004年报告的诊断情况。
1990年至1999年在丹麦出生的所有儿童，共计669995名儿童。
按出生年份分层，每种疾病按年龄划分的累积发病率比例。
自闭症谱系障碍、儿童自闭症、多动障碍和抽动秽语综合征在特定出生年份的累积发病率有统计学意义的增加。强迫症的累积发病率未观察到显著变化。
近期报告的自闭症诊断增加情况在儿童神经精神疾病中可能并非独有，可能是更广泛的流行病学现象的一部分。本研究无法确定报告的累积发病率变化的共同模式的原因，但数据强调了总体上对神经发育障碍儿童服务的认识和需求不断增加。
