Department of Child Psychiatry, University of Turku and Turku University Hospital, Lemminkäisenkatu 3/Teutori (3rd floor), 20014, Turku, Finland.
INVEST Research Flagship Center, University of Turku, Turku, Finland.
J Autism Dev Disord. 2021 Sep;51(9):3098-3108. doi: 10.1007/s10803-020-04768-x. Epub 2020 Nov 2.
To examine the risk for premature mortality and intentional self-harm in autism spectrum disorders (ASD). Based on a national birth cohort. Children born in 1987-2005, diagnosed with ASD by 2007 (n = 4695) were matched with four non-ASD subjects (n = 18,450) and followed until 2015 for mortality and intentional self-harm. The risk among ASD subjects was elevated only for natural cause of death. The risk for intentional self-harm was increased in the unadjusted analyses, but decreased to non-significant after adjusting for comorbid psychiatric disorders. ASD subjects are at increased risk for premature mortality due to natural causes of death. While ASD subjects die of suicide and present with more self-harm, the association is explained by comorbid psychiatric disorders.
探讨自闭症谱系障碍（ASD）患者过早死亡和故意自伤的风险。基于全国性的出生队列研究。1987 年至 2005 年间出生的儿童，于 2007 年被诊断为 ASD（n=4695），并与 4 名非 ASD 患者（n=18450）相匹配，随访至 2015 年，观察死亡率和故意自伤情况。ASD 患者的自然死因死亡风险升高。在未调整分析中，故意自伤风险增加，但在调整共患精神障碍后，风险降低至无统计学意义。ASD 患者因自然原因导致过早死亡的风险增加。虽然 ASD 患者死于自杀且更易出现自伤，但这种关联可由共患精神障碍来解释。
