Division of Metabolic, Endocrine and Minimally Invasive Surgery, Department of Surgery, Mount Sinai School of Medicine, New York, NY 10029, USA.
Obes Surg. 2011 Feb;21(2):244-52. doi: 10.1007/s11695-010-0305-x.
Bariatric surgery is the most effective modality of achieving weight loss as well as the most effective treatment for type 2 diabetes mellitus (T2DM). Glucose-dependent insulinotropic polypeptide (GIP) is an incretin and is implicated in the pathogenesis of obesity and T2DM. Its role in weight loss and resolution of T2DM after bariatric surgery is very controversial. We have made an attempt to review the physiology of GIP and its role in weight loss and resolution of T2DM after bariatric surgery. We searched PubMed and included all relevant original articles (both human and animal) in the review. Whereas most human studies have shown a decrease in GIP post-malabsorptive bariatric surgery, the role of GIP in bariatric surgery done in animal experiments remains inconclusive.
减重手术是实现体重减轻的最有效方式，也是治疗 2 型糖尿病（T2DM）的最有效方法。葡萄糖依赖性胰岛素释放肽（GIP）是一种肠促胰岛素，与肥胖和 T2DM 的发病机制有关。它在减重手术减轻体重和缓解 T2DM 方面的作用存在很大争议。我们试图回顾 GIP 的生理学及其在减重手术减轻体重和缓解 T2DM 方面的作用。我们检索了 PubMed，并在综述中纳入了所有相关的原始研究（包括人和动物）。虽然大多数人体研究表明，在进行吸收不良的减重手术后，GIP 会减少，但动物实验中减重手术对 GIP 的作用仍不确定。
