Kassner Andrea, Thornhill Rebecca
Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.
Methods Mol Biol. 2011;686:229-45. doi: 10.1007/978-1-60761-938-3_10.
The evaluation of blood-brain barrier (BBB) integrity with contrast-enhanced magnetic resonance imaging (MRI) may prove valuable in the setting of certain brain pathologies, such as brain tumors and acute ischemic stroke. Various MRI protocols have been developed to explore the integrity of the BBB by monitoring the leakage of intravenously administered contrast medium into the brain parenchyma. In its simplest form, BBB integrity is assessed qualitatively, by determining the presence or absence of contrast-enhancement on a structural MR image. When a dynamic contrast-enhanced (DCE) MRI protocol is combined with a suitable pharmacokinetic model, DCE-MRI can map the spatial distribution of BBB integrity throughout the brain and assist with evaluating the effects of therapy. Several model-free surrogate measures of BBB permeability have been recently proposed, all of which can be readily computed from standard dynamic susceptibility contrast MRI perfusion scans. Contrast-enhanced MRI offers multiple strategies for evaluating BBB integrity.
利用对比增强磁共振成像（MRI）评估血脑屏障（BBB）的完整性，在某些脑部病变（如脑肿瘤和急性缺血性中风）的情况下可能具有重要价值。已经开发了各种MRI方案，通过监测静脉注射造影剂向脑实质的渗漏来探索BBB的完整性。最简单的形式是通过在结构MR图像上确定有无对比增强来定性评估BBB的完整性。当动态对比增强（DCE）MRI方案与合适的药代动力学模型相结合时，DCE-MRI可以绘制出全脑BBB完整性的空间分布，并有助于评估治疗效果。最近提出了几种无模型的BBB通透性替代测量方法，所有这些方法都可以从标准的动态磁敏感对比MRI灌注扫描中轻松计算出来。对比增强MRI提供了多种评估BBB完整性的策略。
