Department of Medical Imaging, University of Toronto, 150 College Street, Room 125, Toronto, ON M5S 3E2, Canada.
Neuroimaging Clin N Am. 2011 May;21(2):315-25, x-xi. doi: 10.1016/j.nic.2011.01.004. Epub 2011 Mar 16.
The blood-brain barrier (BBB) is a functional concept to describe unique features of intracranial blood vessels that prevent many substances in the systemic circulation from entering the brain. In the setting of acute ischemic stroke, loss of blood-brain barrier (BBB) integrity is believed to be a precursor to hemorrhagic transformation. CT and MR imaging may evaluate BBB integrity by detecting leakage of intravenously administered contrast media into the extravascular space. In its simplest form, BBB integrity is assessed qualitatively, by determining the presence or absence of contrast enhancement on structural images of the brain. When dynamic contrast-enhanced (DCE) MRI or CT is combined with a suitable pharmacokinetic model, one can quantify and spatially map BBB integrity throughout the brain.
血脑屏障（BBB）是一个功能概念，用于描述颅内血管的独特特征，这些特征可防止许多在体循环中的物质进入大脑。在急性缺血性脑卒中的情况下，血脑屏障（BBB）的完整性丧失被认为是出血转化的前兆。CT 和 MRI 可以通过检测静脉内给予的对比剂漏入血管外间隙来评估 BBB 完整性。最简单的形式是通过确定脑结构图像上是否存在对比增强来定性评估 BBB 完整性。当动态对比增强（DCE）MRI 或 CT 与合适的药代动力学模型结合使用时，可以定量和空间映射整个大脑的 BBB 完整性。
