Seitz Michael
Universitätsklinik für Rheumatologie, Klinische Immunologie und Allergologie, Inselspital Bern.
Praxis (Bern 1994). 2010 Nov 17;99(23):1429-34. doi: 10.1024/1661-8157/a000311.
The detection of autoantibodies is an important cornerstone in the diagnosis of systemic autoimmune disorders such as autoimmune connectivitides and small vessel vasculitides. Antinuclear antibodies (ANAs ) and antineutrophil cytoplasmic antibodies (c+p-ANCAs) are appropriate diagnostic screening tools for autoimmune connectivitides and small vessel vasculitides. For economic and intellectual/didactic reasons more extensive autoantibody diagnostics should be performed only in particular situations when patients history and clinical exam lead to strong diagnostic suspicion.
自身抗体的检测是诊断系统性自身免疫性疾病（如自身免疫性结缔组织病和小血管炎）的重要基石。抗核抗体（ANA）和抗中性粒细胞胞浆抗体（c+p-ANCA）是自身免疫性结缔组织病和小血管炎合适的诊断筛查工具。出于经济和知识/教学方面的原因，只有在患者病史和临床检查引发强烈诊断怀疑的特定情况下，才应进行更广泛的自身抗体诊断。
