通过单步或顺序交叉偶联来获得结构多样的 4-喹诺酮的不同途径。
Divergent route to access structurally diverse 4-quinolones via mono or sequential cross-couplings.
机构信息
Department of Chemistry, University of South Florida, CHE205, 4202 East Fowler Avenue, Tampa, Florida 33620, United States.
出版信息
J Org Chem. 2010 Dec 17;75(24):8654-7. doi: 10.1021/jo1014504. Epub 2010 Nov 17.
PMID:21082793
Abstract
A divergent route was developed to access 3-iodo- and 6-chloro-3-iodo-4(1H)-quinolones for further elaboration via mono and/or sequential Suzuki-Miyaura cross-coupling to generate novel and medicinally important 4(1H)-quinolones. Copper- and palladium-catalyzed cyanations were used to functionalize the 4-quinolone core further.
摘要
开发了一条发散路线，以获得 3-碘-和 6-氯-3-碘-4(1H)-喹诺酮，以便通过单步和/或顺序 Suzuki-Miyaura 交叉偶联进一步进行阐述，从而生成新型且具有医学重要性的 4(1H)-喹诺酮。使用铜和钯催化的氰化反应进一步官能化 4-喹诺酮核心。
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