手性钌路易斯酸催化的分子内 Diels-Alder 反应。
Chiral ruthenium Lewis acid catalyzed intramolecular Diels-Alder reactions.
机构信息
Department of Organic Chemistry, University of Geneva, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland.
出版信息
Org Lett. 2010 Dec 17;12(24):5604-7. doi: 10.1021/ol1019103. Epub 2010 Nov 17.
PMID:21082811
Abstract
Single point binding ruthenium Lewis acid catalysts [Ru(acetone)(S,S)-BIPHOP-F)Cp][SbF(6)] ((S,S)-1b) and [Ru(acetone)(S,S)-BIPHOP-F)(indenyl)][SbF(6)] ((S,S)-1c) efficiently catalyze intramolecular Diels-Alder (IMDA) reactions under mild conditions to afford the endo cycloaddition products as the major product in excellent yields with high diastereo- and enantioselectivities.
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