Paul D Coverdell Center for Biomedical & Health Sciences, Department of Biochemistry & Molecular Biology, University of Georgia, 500 DW Brooks Drive, Athens, GA 30602, USA.
Regen Med. 2010 Nov;5(6):947-59. doi: 10.2217/rme.10.79.
The interplay between transcription factors, epigenetic modifiers, chromatin remodelers and miRNAs form the foundation of a complex regulatory network required for establishment and maintenance of the pluripotent state. Recent work indicates that Myc transcription factors are essential elements of this regulatory system. However, despite numerous studies, aspects of how Myc controls self-renewal and pluripotency remain obscure. This article reviews evidence supporting the placement of Myc as a central regulator of the pluripotent state and discusses possible mechanisms of action.
转录因子、表观遗传修饰物、染色质重塑因子和 miRNA 之间的相互作用构成了一个复杂的调控网络的基础，该网络对于多能状态的建立和维持是必需的。最近的工作表明，Myc 转录因子是该调控系统的重要组成部分。然而，尽管进行了大量的研究，Myc 如何控制自我更新和多能性的各个方面仍然不清楚。本文综述了支持 Myc 作为多能状态的中央调控因子的证据，并讨论了可能的作用机制。
