Narasimha Raghavendra B, Shreya Singireddy, Jayabal Vijay Anand, Yadav Vikas, Rath Prasana Kumar, Mishra Bidyut Prava, Kancharla Sudhakar, Kolli Prachetha, Mandadapu Gowtham, Kumar Sudarshan, Mohanty Ashok Kumar, Jena Manoj Kumar
Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, India.
Department of Animal Biotechnology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University, Chennai 600051, Tamil Nadu, India.
Vet Sci. 2025 Jan 17;12(1):67. doi: 10.3390/vetsci12010067.
Stem cells are unique, undifferentiated cells that have the ability to both replicate themselves and develop into specialized cell types. This dual capability makes them valuable in the development of regenerative medicine. Current development in stem cell research has widened their application in cell therapy, drug discovery, reproductive cloning in animals, and cell models for various diseases. Although there are substantial studies revealing the treatment of human degenerative diseases using stem cells, this is yet to be explored in livestock animals. Many diseases in livestock species such as mastitis, laminitis, neuromuscular disorders, autoimmune diseases, and some debilitating diseases are not covered completely by the existing drugs and treatment can be improved by using different types of stem cells like embryonic stem cells, adult stem cells, and induced pluripotent stem cells. This review mainly focuses on the use of stem cells for disease treatment in livestock animals. In addition to the diseases mentioned, the potential of stem cells can be helpful in wound healing, skin disease therapy, and treatment of some genetic disorders. This article explores the potential of stem cells from various sources in the therapy of livestock diseases and also their role in the conservation of endangered species as well as disease model preparation. Moreover, the future perspectives and challenges associated with the application of stem cells in livestock are discussed. Overall, the transformative impact of stem cell research on the livestock sector is comprehensively studied which will help researchers to design future research work on stem cells related to livestock diseases.
干细胞是独特的未分化细胞，具有自我复制和发育成特定细胞类型的能力。这种双重能力使它们在再生医学的发展中具有重要价值。干细胞研究的当前进展拓宽了它们在细胞治疗、药物发现、动物生殖克隆以及各种疾病细胞模型中的应用。尽管有大量研究揭示了使用干细胞治疗人类退行性疾病，但在牲畜动物中尚未进行探索。牲畜物种中的许多疾病，如乳腺炎、蹄叶炎、神经肌肉疾病、自身免疫性疾病以及一些使人衰弱的疾病，现有药物并未完全涵盖，使用胚胎干细胞、成体干细胞和诱导多能干细胞等不同类型的干细胞可以改善治疗效果。这篇综述主要关注干细胞在牲畜动物疾病治疗中的应用。除了上述疾病外，干细胞的潜力在伤口愈合、皮肤病治疗以及一些遗传疾病的治疗中可能也有帮助。本文探讨了各种来源的干细胞在牲畜疾病治疗中的潜力，以及它们在濒危物种保护和疾病模型制备中的作用。此外，还讨论了干细胞在牲畜应用中的未来前景和挑战。总体而言，全面研究了干细胞研究对牲畜领域的变革性影响，这将有助于研究人员设计与牲畜疾病相关的干细胞未来研究工作。
