Parkin Mark C, Brailsford Alan D
King's College London, Drug Control Centre, Department of Forensic Science & Drug Monitoring, 150 Stamford Street, London, SE1 9NH, UK.
Bioanalysis. 2009 Aug;1(5):1001-13. doi: 10.4155/bio.09.70.
Reported incidences of drug-facilitated sexual assault (DFSA) are on the increase worldwide. These cases represent a particular challenge for the forensic toxicologist due to the difficulty in obtaining adequate evidence of drug administration. Primarily, this is due to the nature and diversity of the drugs involved, their pharmacology and sampling timescales. Evaluating whether a drug has been administered to a victim for the purpose of sexual assault can often be difficult, if not impossible. This review draws attention to this burgeoning crime and focuses on the unique challenges DFSA cases present in terms of evidential analysis. Current analytical methodologies for investigating DFSA are highlighted and discussed along with developments in improving analytical procedures. In particular, enlarging detection windows by adopting emerging LC-MS techniques is also discussed. This review also highlights the use of cutting-edge technologies such as ultra-HPLC and the use of alternative matrices for addressing the problem of improved retrospective drug detection.
据报道，药物辅助性侵犯（DFSA）在全球范围内的发生率正在上升。由于难以获得足够的药物施用证据，这些案件对法医毒理学家来说是一项特殊挑战。主要原因在于所涉药物的性质和多样性、其药理学以及采样时间尺度。评估是否为了性侵犯目的而向受害者施用药物往往很困难，甚至不可能。本综述提请关注这一新兴犯罪，并重点关注DFSA案件在证据分析方面所带来的独特挑战。文中突出并讨论了目前用于调查DFSA的分析方法以及改进分析程序的进展。特别还讨论了通过采用新兴的液相色谱 - 质谱技术来扩大检测窗口。本综述还强调了使用超高效液相色谱等前沿技术以及使用替代基质来解决改进追溯性药物检测问题的情况。
