Teale Phil, Barton Chris, Driver Philip M, Kay Richard G
HFL Sport Science, Quotient Bioresearch Ltd, Newmarket Road, Fordham, Cambridgeshire, B7 5WW, UK.
Bioanalysis. 2009 Sep;1(6):1103-18. doi: 10.4155/bio.09.87.
The fight against doping in sport using analytical chemistry is a mature area with a history of approximately 100 years in horse racing and at least 40 years in human sport. Over that period, the techniques used and the breadth of coverage have developed significantly. These improvements in the testing methods have been matched by the increased sophistication of the methods, drugs and therapies available to the cheat and, as a result, testing has been a reactive process constantly adapting to meet new threats. Following the inception of the World Anti-Doping Agency, research into the methods and technologies available for human doping control have received coordinated funding on an international basis. The area of biomarker research has been a major beneficiary of this funding. The aim of this article is to review recent developments in the application of biomarkers to doping control and to assess the impact this could make in the future.
利用分析化学打击体育界的兴奋剂问题是一个成熟的领域，在赛马运动中有大约100年的历史，在人类体育赛事中至少有40年的历史。在那段时间里，所使用的技术和覆盖范围都有了显著发展。检测方法的这些改进与作弊者可用的方法、药物和疗法日益复杂相匹配，因此，检测一直是一个不断适应新威胁的反应性过程。自世界反兴奋剂机构成立以来，对用于人类兴奋剂检测的方法和技术的研究在国际范围内获得了协调资金。生物标志物研究领域一直是这笔资金的主要受益者。本文旨在综述生物标志物在兴奋剂检测应用中的最新进展，并评估其未来可能产生的影响。
