McKinney Andrew R
Australian Racing Forensic Laboratory, PO Box 528, Kensington, NSW 1465, Australia.
Bioanalysis. 2009 Jul;1(4):785-803. doi: 10.4155/bio.09.52.
Control of the use of performance-affecting substances in the horse is critical to the integrity of a wide range of equine sports, with major implications for both animal welfare and revenue streams. One class of medications enjoying particular public notoriety is the anabolic-androgenic steroid group, as highlighted by the recent 'Big Brown' affair and Congressional inquiries into the use of steroids in professional sports, including horse racing, in the USA. This review examines the latest developments pertaining to the analytical detection of these substances in equine biological samples and the supporting regulatory environment. Consideration is given to the full variety of sample matrices available, together with modern sample preparative approaches and instrumental techniques. Issues concerning the regulation of endogenous steroids, including thresholds where applicable, are also discussed.
控制马匹中使用影响性能的物质对于广泛的马术运动的公正性至关重要，这对动物福利和收入来源都有重大影响。一类特别引起公众关注的药物是合成代谢雄激素类固醇，最近的“大布朗”事件以及美国国会对包括赛马在内的职业体育中使用类固醇的调查就突出了这一点。本综述探讨了与在马生物样本中分析检测这些物质以及支持性监管环境相关的最新进展。考虑了可用的各种样本基质，以及现代样本制备方法和仪器技术。还讨论了与内源性类固醇监管有关的问题，包括适用的阈值。
