Teale Philip, Houghton Edward
HFL Sport Science, Newmarket Road, Fordham, Cambridgeshire, CB7 5WW, UK.
Bioanalysis. 2010 Jun;2(6):1085-107. doi: 10.4155/bio.10.57.
The fight against doping in sport using analytical chemistry is a mature area with a history of approximately 100 years in horseracing. In common with human sport, anabolic/androgenic steroids (AASs) are an important group of potential doping agents. Particular issues with their detection are extensive metabolism including both phase I and phase II. A number of the common AASs are also endogenous to the equine. A further issue is the large number of synthetic steroids produced as pharmaceutical products or as 'designer' drugs intended to avoid detection or for the human supplement market. An understanding of the metabolism of AASs is vital to the development of effective detection methods for equine sport. The aim of this paper is to review current knowledge of the metabolism of appropriate steroids, the current approaches to their detection in equine sport and future trends that may affect equine dope testing.
利用分析化学打击赛马运动中的兴奋剂问题是一个成熟的领域，在赛马运动中已有约100年的历史。与人类体育一样，合成代谢/雄性激素类固醇（AASs）是一类重要的潜在兴奋剂。其检测的特殊问题包括广泛的代谢，涵盖I相和II相。许多常见的AASs在马体内也是内源性的。另一个问题是作为药品或旨在逃避检测的“设计”药物或用于人类补充剂市场而生产的大量合成类固醇。了解AASs的代谢对于开发有效的赛马运动检测方法至关重要。本文的目的是综述关于适当类固醇代谢的现有知识、目前在赛马运动中检测它们的方法以及可能影响赛马兴奋剂检测的未来趋势。
