Bach Dylan M, Straseski Joely A, Clarke William
Univeristy of California, Irvine, Department of Pathology, Irvine, CA, USA.
Bioanalysis. 2010 May;2(5):863-79. doi: 10.4155/bio.10.48.
For a select number of drugs, proper management of patients includes monitoring serum or plasma concentrations of the drugs and adjusting the doses accordingly - this practice is referred to as therapeutic drug monitoring (TDM). The need for TDM arises when pharmacokinetic variability of drugs is not easily accounted for by common clinical parameters. Many chemotherapeutic drugs have large interindividual variability, yet TDM is not commonplace in chemotherapy management. This review will discuss pharmacokinetics in the context of chemotherapeutic drugs, examine the few instances where TDM is currently used in the field of oncology and propose other drugs where TDM might be useful for dose adjustments in the management of chemotherapy.
对于某些特定药物，对患者的合理管理包括监测药物的血清或血浆浓度并相应调整剂量——这种做法被称为治疗药物监测（TDM）。当普通临床参数难以解释药物的药代动力学变异性时，就需要进行TDM。许多化疗药物存在较大的个体间变异性，但TDM在化疗管理中并不常见。本综述将在化疗药物的背景下讨论药代动力学，研究目前肿瘤学领域中使用TDM的少数情况，并提出其他可能有助于化疗管理中剂量调整的药物。
