Jaworska Aleksandra, Fornasaro Stefano, Sergo Valter, Bonifacio Alois
Department of Engineering and Architecture, University of Trieste, Via Valerio 6a, 34127 Trieste, Italy.
Biosensors (Basel). 2016 Sep 19;6(3):47. doi: 10.3390/bios6030047.
Surface-Enhanced Raman Spectroscopy (SERS) is a label-free technique that enables quick monitoring of substances at low concentrations in biological matrices. These advantages make it an attractive tool for the development of point-of-care tests suitable for Therapeutic Drug Monitoring (TDM) of drugs with a narrow therapeutic window, such as chemotherapeutic drugs, immunosuppressants, and various anticonvulsants. In this article, the current applications of SERS in the field of TDM for cancer therapy are discussed in detail and illustrated according to the different strategies and substrates. In particular, future perspectives are provided and special concerns regarding the standardization of self-assembly methods and nanofabrication procedures, quality assurance, and technology readiness are critically evaluated.
表面增强拉曼光谱（SERS）是一种无标记技术，能够快速监测生物基质中低浓度的物质。这些优势使其成为开发适用于治疗窗狭窄药物（如化疗药物、免疫抑制剂和各种抗惊厥药）治疗药物监测（TDM）的即时检测的有吸引力的工具。在本文中，将根据不同的策略和底物，详细讨论并举例说明SERS在癌症治疗TDM领域的当前应用。特别是，提供了未来展望，并对自组装方法和纳米制造程序的标准化、质量保证和技术成熟度等特殊问题进行了批判性评估。
