Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia.
Vector Borne Zoonotic Dis. 2011 Jul;11(7):883-9. doi: 10.1089/vbz.2010.0018. Epub 2010 Nov 17.
Limited data exist on differences of erythema migrans patients with either positive or negative Borrelia burgdorferi sensu lato skin culture.
We analyzed 252 adult patients with erythema migrans in whom skin biopsy specimen was cultured for the presence of B. burgdorferi sensu lato. Evaluations of epidemiological, clinical, and microbiological findings were conducted at baseline, 14 days, 2, 6, and 12 months after treatment with either doxycycline or cefuroxime axetil.
One hundred fifty-one (59.9%) patients had positive skin culture (86.9% B. afzelii, 8.0% B. garinii, 5.1% B. burgdorferi sensu stricto) and 101 (40.1%) had negative skin culture. Patients in the culture-positive and culture-negative groups were comparable for the basic demographic, epidemiological, clinical, and laboratory characteristics at presentation. Statistically significantly worse selected treatment outcome parameters in the culture-positive group compared with the culture-negative group were established during follow-up. Treatment failure was documented in two patients who were culture positive and in none in the culture-negative group.
Although findings for the pretreatment characteristics were comparable between the erythema migrans skin culture-positive and culture-negative patients, some parameters indicate that borrelia skin culture positivity may predict a less-favorable treatment outcome.
关于皮肤培养呈阳性或阴性的伯氏疏螺旋体病患者之间的差异，现有数据有限。
我们分析了 252 例成人游走性红斑患者，对其皮肤活检标本进行了伯氏疏螺旋体病的培养。在接受多西环素或头孢呋辛酯治疗后，分别在基线、14 天、2、6 和 12 个月时，对流行病学、临床和微生物学发现进行了评估。
151 例（59.9%）患者的皮肤培养呈阳性（86.9%阿氏疏螺旋体、8.0%伽氏疏螺旋体、5.1%伯氏疏螺旋体），101 例（40.1%）皮肤培养呈阴性。在就诊时，培养阳性组和培养阴性组的基本人口统计学、流行病学、临床和实验室特征相当。在随访期间，与培养阴性组相比，培养阳性组的某些治疗结局参数明显更差。在培养阳性组中有两名患者治疗失败，而在培养阴性组中则没有。
尽管游走性红斑皮肤培养阳性和阴性患者的治疗前特征相似，但有些参数表明伯氏疏螺旋体皮肤培养阳性可能预示着治疗结局较差。
