Nomura Masayo, Maeda Manabu, Seishima Mariko
Department of Dermatology, Gifu Prefecture General Hospital of Medicine, Yanagido, Gifu City, Japan.
J Dermatol. 2010 Dec;37(12):1046-50. doi: 10.1111/j.1346-8138.2010.00973.x. Epub 2010 Sep 28.
Phaeohyphomycosis is a rare fungal infection that is more commonly associated with compromised patients. We present herein an 81-year-old man with collagen disease and chronic interstitial pneumonia who developed subcutaneous phaeohyphomycosis caused by Exophiala jeanselmei. The main pathogen of phaeohyphomycosis had been considered to be E. jeanselmei complex. This has recently been divided into several species by using a molecular technique. The main pathogen of phaeohyphomycosis is Exophiala xenobiotica, and E. jeanselmei is rather a rare pathogen of this disease. Although p.o. itraconazole and terbinafine administration was not effective for this patient, these antifungal agents were used for preventing systemic dissemination in this immunocompromised host.
暗色丝孢霉病是一种罕见的真菌感染，更常见于免疫功能低下的患者。我们在此报告一名81岁患有胶原病和慢性间质性肺炎的男性，他发生了由琼氏外瓶霉引起的皮下暗色丝孢霉病。暗色丝孢霉病的主要病原体曾被认为是琼氏外瓶霉复合体。最近通过分子技术将其分为几个种。暗色丝孢霉病的主要病原体是异源外瓶霉，而琼氏外瓶霉是这种疾病相当罕见的病原体。尽管口服伊曲康唑和特比萘芬对该患者无效，但这些抗真菌药物用于预防这个免疫功能低下宿主的全身播散。
