右手外瓶霉引起的皮肤暗色丝孢霉病：病例报告及文献复习。
Cutaneous Phaeohyphomycosis of the Right Hand Caused by Exophiala jeanselmei: A Case Report and Literature Review.
机构信息
Department of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China.
West China School of Medicine, Sichuan University, Chengdu, 610041, China.
出版信息
Mycopathologia. 2022 Jun;187(2-3):259-269. doi: 10.1007/s11046-022-00623-y. Epub 2022 Mar 21.
Exophiala spp. is increasingly reported as a pathogen causing the cutaneous, subcutaneous or invasive infection. In this report, we present a case of cutaneous phaeohyphomycosis due to E. jeanselmei on the right hand of a farmer, who suffered from this disease three years ago which had not been definitely diagnosed until he was admitted to our hospital. In our hospital, a potential fungal pathogen was observed by histopathological examination, and then was recovered and identified as E. jeanselmei by sequencing its internal transcribed spacer region. After 4 weeks of antifungal treatment, his hand recovered very well. To investigate the in vitro susceptibility of E. jeanselmei isolates to antifungal agents and compare the characteristics of their related infections among immunocompetent and immunocompromised patients, we reviewed 84 cases published in PubMed database between 1980 and 2020.
外瓶霉属越来越多地被报道为导致皮肤、皮下或侵袭性感染的病原体。在本报告中，我们介绍了一位农民右手患有外瓶霉属詹氏外瓶霉引起的皮肤暗色丝孢霉病的病例，他在三年前就患有该病，但直到他入住我院才被明确诊断。在我院，通过组织病理学检查观察到一种潜在的真菌病原体，然后通过测序其内部转录间隔区将其鉴定为詹氏外瓶霉。经过 4 周的抗真菌治疗，他的手恢复得很好。为了研究詹氏外瓶霉分离株对抗真菌药物的体外敏感性，并比较免疫功能正常和免疫功能低下患者相关感染的特征，我们回顾了 1980 年至 2020 年期间在 PubMed 数据库中发表的 84 例病例。
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