Shapshay S M, Aretz H T, Setzer S E
Department of Otolaryngology-Head and Neck Surgery, Lahey Clinic Medical Center, Burlington, MA 01805.
Otolaryngol Head Neck Surg. 1990 Mar;102(3):251-6. doi: 10.1177/019459989010200308.
A holmium-yttrium scandium gallium garnet laser is a pulsed mid-infrared crystalline laser (wavelength, 2.1 microns), which is easily transmissible through flexible quartz fibers. With use of a 300-microns fiber delivery system, this laser was applied in the canine trachea to create a standard 5-mm diameter lesion through mucosa and submucosa. Power settings of 400 mJ and 600 mJ per pulse at 2 pulses per second were used, and wound healing was studied over a 2-week period. Excellent control of depth of tissue ablation was noted, with uncomplicated wound repair. Although healing was somewhat slower compared with healing when the CO2 laser was used, less granulation and fewer inflammatory changes were noted. Further studies need to be performed to determine ideal laser dosimetry before this laser is applied clinically.
钬钇钪镓石榴石激光是一种脉冲式中红外晶体激光（波长为2.1微米），它很容易通过柔性石英纤维进行传输。使用300微米的光纤传输系统，将这种激光应用于犬类气管，以通过黏膜和黏膜下层形成一个标准的直径5毫米的损伤。使用每秒2个脉冲、每个脉冲400毫焦和600毫焦的功率设置，并在2周的时间内研究伤口愈合情况。结果显示对组织消融深度的控制极佳，伤口修复过程顺利。虽然与使用二氧化碳激光时的愈合情况相比，愈合速度稍慢，但观察到肉芽组织较少且炎症变化较少。在该激光临床应用之前，需要进行进一步研究以确定理想的激光剂量。
