Medical Ultrasound Physics and Technology Group, School of Physics, Dublin Institute of Technology, Dublin, Ireland.
Ultrasound Med Biol. 2011 Jan;37(1):122-35. doi: 10.1016/j.ultrasmedbio.2010.10.005. Epub 2010 Nov 16.
The development and acoustical characterisation of a range of novel agar-based tissue mimicking material (TMMs) for use in clinically relevant, quality assurance (QA) and anthropomorphic breast phantoms are presented. The novel agar-based TMMs described in this study are based on a comprehensive, systematic variation of the ingredients in the International Electrotechnical Commission (IEC) TMM. A novel, solid fat-mimicking material was also developed and acoustically characterised. Acoustical characterisation was carried out using an in-house scanning acoustic macroscope at low (7.5 MHz) and high frequencies (20 MHz), using the pulse-echo insertion technique. The speeds of sound range from 1490 to 1570 m. s(-1), attenuation coefficients range from 0.1 to 0.9 dB. cm(‑1). MHz(-1) and relative backscatter ranges from 0 to -20 dB. It was determined that tissues can be mimicked in terms of independently controllable speeds of sound and attenuation coefficients. These properties make these novel TMMs suitable for use in clinically relevant QA and anthropomorphic phantoms and would potentially be useful for other high frequency applications such as intravascular and small animal imaging.
本文介绍了一系列新型琼脂基组织模拟材料（TMM）的开发和声学特性，这些材料可用于临床相关、质量保证（QA）和拟人化乳房体模。本研究中描述的新型琼脂基 TMM 基于国际电工委员会（IEC）TMM 成分的全面、系统变化。还开发并声学特性化了一种新颖的固体脂肪模拟材料。使用内部扫描声学显微镜，在低（7.5 MHz）和高频率（20 MHz）下，使用脉冲回波插入技术进行声学特性化。声速范围从 1490 到 1570 m/s，衰减系数范围从 0.1 到 0.9 dB/cm/MHz，相对背散射范围从 0 到-20 dB。确定可以根据独立控制的声速和衰减系数来模拟组织。这些特性使得这些新型 TMM 适合用于临床相关 QA 和拟人化体模，并且可能对其他高频应用（如血管内和小动物成像）有用。
