Central Laboratory, College of Basic Medical Sciences, Third Military Medical University, Chongqing 400038, PR China.
Med Hypotheses. 2011 Mar;76(3):314-6. doi: 10.1016/j.mehy.2010.09.022. Epub 2010 Nov 16.
The prevention of peritendinous adhesions after zone II flexor tendon repair poses a significant challenge to hand surgeons. Exogenous hyaluronic acid (HA) has been widely studied and has been found to promote tendon healing and decrease adhesion formation in digital flexor tendons following surgery. However, the clinical application of exogenous HA is restricted due to limitations inherent in the exogenously expressed form. However, hyaluronic acid synthase 2 (has2) has been shown to promote synthesis of the endogenous high molecular weight HA in many cells. Taken together with the fact that synovium-derived mesenchymal stem cells (SMSCs) are more proliferative than other MSCs, we hypothesize that over-expression of has2 in SMSCs will be an effective therapeutic in preventing the adhesions in surgery of the digital flexor tendons.
预防 II 区屈肌腱修复术后的腱周粘连对手外科医生来说是一个巨大的挑战。外源性透明质酸（HA）已被广泛研究，并且已被发现可促进手术后手指屈肌腱的愈合并减少粘连形成。然而，由于外源性表达形式的固有局限性，外源性 HA 的临床应用受到限制。然而，透明质酸合酶 2（has2）已被证明可促进许多细胞中内源性高分子量 HA 的合成。结合滑膜来源的间充质干细胞（SMSCs）比其他间充质干细胞具有更强的增殖能力这一事实，我们假设 SMSCs 中 has2 的过表达将成为预防手指屈肌腱手术粘连的有效治疗方法。
