Ozgenel G Y
Department of Plastic and Reconstructive Surgery, Division of Hand Surgery, Uludağ University Medical School, Bursa, Turkey.
J Bone Joint Surg Br. 2004 Mar;86(2):301-7. doi: 10.1302/0301-620x.86b2.14435.
We have investigated the effects of the intra-operative application of a combination of hyaluronic acid and amniotic membrane on adhesions in the flexor tendons of a chicken model. We used 144 tendons which were partially divided and then repaired by a modified Kessler technique. There were four test groups: group 1, simple tendon repair, group 2, repair site wrapped with amniotic membrane, group 3, hyaluronic acid injected around the repair site, and group 4, repair site wrapped with amniotic membrane and hyaluronic acid injected within it. At three and six weeks, the extent of the adhesions and the healing of the tendon were evaluated macroscopically and histologically. The range of movement of the toe and tensile strength of the repaired tendons were measured at 20 weeks. The least adhesions were observed in group 4 but no significant difference was found in the healing of the tendons. Overall, the intra-operative application of a combination of hyaluronic acid and amniotic membrane appears to be effective in preventing adhesions of the flexor tendon.
我们研究了术中应用透明质酸和羊膜联合制剂对鸡模型屈指肌腱粘连的影响。我们使用144根肌腱，将其部分切断，然后采用改良的凯斯勒技术进行修复。共有四个试验组：第1组，单纯肌腱修复；第2组，用羊膜包裹修复部位；第3组，在修复部位周围注射透明质酸；第4组，用羊膜包裹修复部位并在其中注射透明质酸。在3周和6周时，通过宏观和组织学方法评估粘连程度和肌腱愈合情况。在20周时测量趾部的活动范围和修复肌腱的抗张强度。第4组观察到的粘连最少，但在肌腱愈合方面未发现显著差异。总体而言，术中应用透明质酸和羊膜联合制剂似乎对预防屈指肌腱粘连有效。
