Rodríguez Claudia Izquierdo, Cadenas-Sanchez Cristina, Santos José L, Ruiz Jonatan R, Medrano María, Martínez-Vizcaíno Vicente, Goran Michael I, Labayen Idoia
Department of Health Sciences, ELIKOS Group, Institute for Sustainability and Food Chain Innovation (IS-FOOD), Public University of Navarre, Pamplona, Spain.
IdiSNA: Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
EClinicalMedicine. 2025 May 6;83:103205. doi: 10.1016/j.eclinm.2025.103205. eCollection 2025 May.
Intrapancreatic fat deposition is associated with increased cardiovascular risk in adults, but the association is less clear in children. Our goal in this work was therefore to conduct a systematic review and meta-analysis of the associations between intrapancreatic fat deposition with adiposity and components of metabolic syndrome in children and adolescents.
Systematic searches were conducted in MEDLINE, Web of Science, and Scopus from database inception to January 11, 2025 (registration number: CRD42022374159). Random-effects meta-analysis was performed to obtain pooled correlations estimates of the association of intrapancreatic fat deposition with various adiposity related outcomes (i.e., overall/central adiposity and specific fat depots; primary outcome) and cardiometabolic risk factors (i.e., glycaemic traits, insulin resistance/sensitivity, insulin secretion surrogates, plasma lipids, and blood pressure; secondary outcomes). Risk of bias and the quality of evidence were evaluated.
We identified a total of 252 studies, of which 15 unique studies (N = 1261 participants, mean age ranged 10.6-17.7 years, 44.4% females) were eligible for meta-analysis. Magnetic resonance imaging-measured intrapancreatic fat deposition showed a small to medium positive significant association with adiposity (n = 53 studies, r = 0.24 [95% CI:0.19; 0.29], I = 61.5%), impaired glycaemic traits and insulin sensitivity (n = 11 studies, r = 0.15 [95% CI:0.03; 0.26], I = 58.9%), and HDL levels (n = 7 studies, pooled r = 0.11 [95% CI: 0.01; 0.20], I = 0%), and increased blood pressure (n = 6 studies, pooled r = 0.15 [95% CI: 0.05; 0.25], I = 0%).
Intrapancreatic fat deposition may increase the risk of cardiometabolic disturbances in children. Therefore, it requires more attention in clinical research as an early indicator of ectopic fat deposition, insulin resistance and metabolic syndrome. Longitudinal studies are necessary to understand the temporal dynamics of these associations and to determine the long-term impact of intrapancreatic fat deposition on the risk of developing type 2 diabetes and cardiovascular diseases.
"Plan de Promoción de Grupos de investigación", Public University of Navarre.
胰腺内脂肪沉积与成人心血管风险增加有关，但在儿童中这种关联尚不清楚。因此，我们这项研究的目的是对儿童和青少年胰腺内脂肪沉积与肥胖及代谢综合征各组分之间的关联进行系统评价和荟萃分析。
从数据库建立至2025年1月11日，在MEDLINE、科学网和Scopus中进行系统检索（注册号：CRD42022374159）。采用随机效应荟萃分析来获得胰腺内脂肪沉积与各种肥胖相关结局（即总体/中心性肥胖和特定脂肪堆积部位；主要结局）以及心脏代谢危险因素（即血糖特征、胰岛素抵抗/敏感性、胰岛素分泌替代指标、血脂和血压；次要结局）之间关联的合并相关性估计值。评估偏倚风险和证据质量。
我们共识别出252项研究，其中15项独特研究（N = 1261名参与者，平均年龄10.6 - 17.7岁，44.4%为女性）符合荟萃分析条件。磁共振成像测量的胰腺内脂肪沉积与肥胖呈小到中等程度的显著正相关（n = 53项研究，r = 0.24 [95% CI：0.19；0.29]，I² = 61.5%），与血糖特征受损和胰岛素敏感性呈正相关（n = 11项研究，r = 0.15 [95% CI：0.03；0.26]，I² = 58.9%），与高密度脂蛋白水平呈正相关（n = 7项研究，合并r = 0.11 [95% CI：0.01；0.20]，I² = 0%），与血压升高呈正相关（n = 6项研究，合并r = 0.15 [95% CI：0.05；0.25]，I² = 0%）。
胰腺内脂肪沉积可能会增加儿童心脏代谢紊乱的风险。因此，作为异位脂肪沉积、胰岛素抵抗和代谢综合征的早期指标，它在临床研究中需要更多关注。有必要进行纵向研究以了解这些关联的时间动态，并确定胰腺内脂肪沉积对2型糖尿病和心血管疾病发生风险的长期影响。
纳瓦拉公立大学“研究小组促进计划”。
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