Erny R, Milliet E
Hôpital de la Conception, Marseille.
Rev Fr Gynecol Obstet. 1990 Feb;85(2):73-7.
Medical treatment of fibroma has changed radically in recent years with the introduction of analogs of LH-RH (luteinizing hormone releasing hormone). These agents, which are active only via parenteral administration, have proved remarkably effective, and are devoid of metabolic effects. They do engender some disagreeable adverse reactions, and unfortunately their efficacy is transitory and their cost high. Compared with these analogs, gestrinone, a progestogen as yet unused in treatment of luteal insufficiency, seems very interesting in the treatment of fibromas, due to its prolonged antigonadotropic effect and its antiprogesterone effect. Further studies are required to confirm the first results published by Coutinho.
近年来，随着促黄体生成激素释放激素（LH-RH）类似物的引入，纤维瘤的医学治疗发生了根本性变化。这些药物仅通过肠胃外给药才有活性，已被证明非常有效，且没有代谢作用。它们确实会产生一些令人不适的不良反应，不幸的是，其疗效是暂时的，成本也很高。与这些类似物相比，孕三烯酮是一种尚未用于治疗黄体功能不全的孕激素，由于其延长的抗促性腺激素作用和抗孕酮作用，在纤维瘤的治疗中似乎非常有吸引力。需要进一步研究来证实库蒂尼奥发表的初步结果。
