Public Health from the University of Vale do Itajaí, Santa Catarina, Brazil.
J Clin Rheumatol. 2010 Dec;16(8):365-9. doi: 10.1097/RHU.0b013e3181fe8a90.
Fibromyalgia (FM) is a condition characterized by chronic widespread musculoskeletal pain often associated with sleep disorders and mood and whose pathophysiology is still not clearly defined. In recent years, some studies have hinted at a possible association between different types of pain, including the pain present in FM, with vitamin D deficiency.
The present work consisted of a cross-sectional study aimed at evaluating 25-hydroxyvitamin D (25(OH)D) serum levels in 87 patients with FM, as compared with a control group composed of 92 age- and sex-matched subjects with no chronic musculoskeletal pain. Clinical and laboratory variables that could affect the status of vitamin D were also considered.
There was no statistically significant difference between groups either with respect to mean serum concentration of 25(OH)D or as to the classification of levels as deficient, insufficient, or sufficient. There was no correlation of 25(OH)D levels with pain intensity.
This study showed that light to moderate deficient and insufficient 25(OH)D levels are not found more commonly in patients with FM.
纤维肌痛（FM）是一种以慢性广泛性肌肉骨骼疼痛为特征的疾病，常伴有睡眠障碍和情绪问题，其病理生理学仍未明确界定。近年来，一些研究表明，包括 FM 疼痛在内的不同类型的疼痛与维生素 D 缺乏之间可能存在关联。
本研究是一项横断面研究，旨在评估 87 例 FM 患者和 92 例年龄和性别匹配的无慢性肌肉骨骼疼痛对照组的血清 25-羟维生素 D（25(OH)D）水平。还考虑了可能影响维生素 D 状态的临床和实验室变量。
两组间血清 25(OH)D 平均浓度或缺乏、不足或充足的分类均无统计学差异。25(OH)D 水平与疼痛强度无相关性。
本研究表明，FM 患者中轻至中度缺乏和不足的 25(OH)D 水平并不常见。
