Alonso-Pérez José Luís, Martínez-Pérez Iker, Romero-Morales Carlos, Abuín-Porras Vanesa, López-Bueno Ruben, Rossettini Giacomo, Leigheb Massimiliano, Villafañe Jorge Hugo
Department of Physiotherapy, Faculty of Sport Sciences, Universidad Europea de Madrid, 28670 Villaviciosa de Odón, Spain.
Musculoskeletal Pain and Motor Control Research Group, Faculty of Sport Sciences, Universidad Europea de Madrid, 28670 Villaviciosa de Odón, Spain.
Nutrients. 2024 Nov 26;16(23):4061. doi: 10.3390/nu16234061.
BACKGROUND/OBJECTIVES: Chronic pain impacts approximately 18% of the Spanish population, with low levels of vitamin D prevalent in over 80% of individuals over 65. Given vitamin D's critical role in pain modulation, its deficiency may be significantly linked to chronic musculoskeletal pain, though existing research offers mixed results.
This systematic review followed PRISMA guidelines, examining studies from PubMed, Cochrane, and PEDRO databases from 1990 onwards that investigated the relationship between vitamin D levels and chronic musculoskeletal pain.
A total of 30 studies met the inclusion criteria set by the NHLBI's quality standards. The results are inconclusive regarding the direct relationship between vitamin D levels and chronic musculoskeletal pain due to evidence heterogeneity. However, there appears to be an inverse relationship between vitamin D levels and the intensity of pain.
While the association between vitamin D levels and chronic musculoskeletal pain remains uncertain, the inverse correlation with pain intensity suggests a potential therapeutic role of vitamin D supplementation in pain management. Further research is needed to substantiate these findings and refine intervention strategies.
背景/目的：慢性疼痛影响着约18%的西班牙人口，在65岁以上的人群中，超过80%的人维生素D水平较低。鉴于维生素D在疼痛调节中起关键作用，其缺乏可能与慢性肌肉骨骼疼痛显著相关，尽管现有研究结果不一。
本系统评价遵循PRISMA指南，检索了1990年起PubMed、Cochrane和PEDRO数据库中研究维生素D水平与慢性肌肉骨骼疼痛关系的研究。
共有30项研究符合美国国立心肺血液研究所质量标准设定的纳入标准。由于证据的异质性，关于维生素D水平与慢性肌肉骨骼疼痛之间的直接关系，结果尚无定论。然而，维生素D水平与疼痛强度之间似乎存在负相关。
虽然维生素D水平与慢性肌肉骨骼疼痛之间的关联仍不确定，但与疼痛强度的负相关表明补充维生素D在疼痛管理中可能具有治疗作用。需要进一步研究来证实这些发现并完善干预策略。
