Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clin Nutr ESPEN. 2023 Jun;55:71-75. doi: 10.1016/j.clnesp.2023.03.006. Epub 2023 Mar 9.
BACKGROUND & AIM: The role of vitamin D deficiency in fibromyalgia (FM) pathogenesis is not clearly understood. In this study, we evaluated the association of serum vitamin D status of FM patients with laboratory indices of inflammation, as well as clinical indices of FM.
MATERIALS & METHODS: Ninety-two female FM patients with a mean age of 42.4 ± 7.4 years were included in this cross-sectional study. Serum vitamin D, serum IL-6, and serum IL-8 levels were evaluated using an enzyme-linked immunosorbent assay. Serum vitamin D levels were categorized as deficient (<20 ng/ml), insufficient (20-30 ng/ml), and sufficient (30-100 ng/ml). The clinical severity of the disease was assessed by the fibromyalgia impact questionnaire (FIQ) and widespread pain index (WPI).
The mean serum IL-6 level was significantly higher in vitamin D-deficient patients in comparison with vitamin D-sufficient patients (P = 0.039). The mean serum IL-8 level was also significantly higher in vitamin D-deficient patients in comparison with vitamin D-sufficient patients (P < 0.001). A significant positive correlation was found between the serum IL-8 level and FIQ scores (r = 0.389, p = 0.001) and the WPI of the patients (0.401, p < 0.001). Serum IL-6 level was significantly correlated with the WPI of the patients (r = 0.295, p = 0.004), but not with FIQ scores (r = 0.134, p = 0.066). Serum vitamin D status was not associated with either FIQ scores or WPI.
In FM patients, serum vitamin D deficiency is associated with higher levels of serum pro-inflammatory cytokines, and higher levels of serum pro-inflammatory cytokines are associated with greater FM impact.
维生素 D 缺乏在纤维肌痛（FM）发病机制中的作用尚不清楚。在本研究中，我们评估了 FM 患者血清维生素 D 状态与炎症的实验室指标以及 FM 的临床指标之间的关系。
本横断面研究纳入了 92 名平均年龄为 42.4±7.4 岁的女性 FM 患者。采用酶联免疫吸附试验检测血清维生素 D、血清白细胞介素-6（IL-6）和血清白细胞介素-8（IL-8）水平。血清维生素 D 水平分为缺乏（<20ng/ml）、不足（20-30ng/ml）和充足（30-100ng/ml）。采用纤维肌痛影响问卷（FIQ）和广泛疼痛指数（WPI）评估疾病的临床严重程度。
与维生素 D 充足的患者相比，维生素 D 缺乏的患者血清 IL-6 水平显著升高（P=0.039）。与维生素 D 充足的患者相比，维生素 D 缺乏的患者血清 IL-8 水平也显著升高（P<0.001）。血清 IL-8 水平与 FIQ 评分（r=0.389，p=0.001）和患者的 WPI（r=0.401，p<0.001）呈显著正相关。血清 IL-6 水平与患者的 WPI 显著相关（r=0.295，p=0.004），但与 FIQ 评分无关（r=0.134，p=0.066）。血清维生素 D 状态与 FIQ 评分或 WPI 均无关。
在 FM 患者中，血清维生素 D 缺乏与更高水平的血清促炎细胞因子相关，而更高水平的血清促炎细胞因子与更大的 FM 影响相关。
