Department of Urology, Tulane Health Sciences Center, New Orleans, Louisiana, USA.
Clin Pharmacol Ther. 2011 Jan;89(1):125-8. doi: 10.1038/clpt.2010.215. Epub 2010 Nov 17.
Premature ejaculation (PE) is the most common form of male sexual dysfunction, with an estimated worldwide prevalence of 20–30%.1 Although PE is not life threatening, it has significant impact on quality of life. The fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR)defines PE as “persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the person wishes it” that “causes marked distress or interpersonal difficulty” and “is not due exclusively to the direct effects of a substance.”2 The International Society for Sexual Medicine, which recently modified the definition to include the threshold ejaculatory latency time, defines PEas “male sexual dysfunction characterized by ejaculation which always or nearly always occurs prior to or within 1 min of vaginal penetration; the inability to delay ejaculation on all or nearly all vaginal penetrations; and negative personal consequences such as distress, bother, frustration, and/or the avoidance of sexual intimacy.”3 The lack of ejaculatory control is consistent among all clinical definitions of PE and is a highly sensitive predictor of the condition.
早泄（PE）是最常见的男性性功能障碍形式，估计全球患病率为 20-30%。1 尽管 PE 不会危及生命，但它对生活质量有重大影响。精神障碍诊断与统计手册第四版（DSM-IV-TR）将 PE 定义为“在插入前、插入时或插入后不久，在性刺激最小的情况下，持续或反复发生射精，并且在当事人希望之前发生”，“导致明显的痛苦或人际关系困难”，“不是仅由物质的直接作用引起的”。2 国际性医学会最近修改了定义，包括射精潜伏期的阈值，将 PE 定义为“以射精总是或几乎总是发生在阴道插入之前或之内 1 分钟内为特征的男性性功能障碍；无法延迟所有或几乎所有阴道插入的射精；以及负面的个人后果，如痛苦、烦恼、挫折和/或避免性亲密”。3 在所有关于 PE 的临床定义中，缺乏射精控制是一致的，并且是该病症的高度敏感预测指标。
