Pyrah Department of Urology, St James University Hospital, Leeds, UK.
Ther Adv Urol. 2011 Oct;3(5):211-22. doi: 10.1177/1756287211424172.
Premature ejaculation (PE) is a common male sexual dysfunction. Advances in PE research have been hampered owing to a nonstandardized definition of PE, until the definition by the International Society of Sexual Medicine (ISSM) in 2009. Once the diagnosis of PE is established through a thorough history, a variety of medical therapies is available, including tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), centrally acting opiates, phosphodiesterase 5 inhibitors and topical desensitizing creams. Most of these treatments increase the intravaginal ejaculation latency time (IELT) and patient satisfaction scores, with the most convincing evidence for SSRIs and topical creams. Daily SSRIs such as paroxetine, although efficacious, do have a substantial and prolonged side effect profile. Dapoxetine, which is a on-demand SSRI, is the only licensed drug for the treatment of PE, increasing IELT by a factor of 2.5 to 3 with limited and tolerable side effects. In the near future, the topical aerosol PSD502 is due to be licensed for the treatment of PE, increasing IELT by up to a factor of 6 but having minimal local and negligible systemic side effects.
早泄（PE）是一种常见的男性性功能障碍。由于 PE 的定义不规范，PE 的研究进展一直受到阻碍，直到 2009 年国际性医学会（ISSM）的定义。一旦通过详细的病史确立了 PE 的诊断，就可以使用多种医学治疗方法，包括三环类抗抑郁药、选择性 5-羟色胺再摄取抑制剂（SSRIs）、中枢作用阿片类药物、磷酸二酯酶 5 抑制剂和局部脱敏乳膏。这些治疗方法大多可增加阴道内射精潜伏期（IELT）和患者满意度评分，SSRIs 和局部乳膏的证据最令人信服。虽然每日 SSRIs 如帕罗西汀有效，但确实有明显且持久的副作用。达泊西汀是一种按需 SSRI，是唯一获准用于治疗 PE 的药物，可将 IELT 延长 2.5 至 3 倍，副作用有限且可耐受。在不久的将来，局部喷雾 PSD502 将获准用于治疗 PE，将 IELT 延长高达 6 倍，但局部副作用极小，全身副作用可忽略不计。
