[吡柔比星（THP）与多种抗肿瘤药物对人肿瘤细胞系的体外联合作用]

[In vitro combined effects of pirarubicin (THP) and various antitumor drugs on human tumor cell lines].

作者信息

Nagasawa M, Ishii S, Kariya Y, Itoh O, Yamamoto H, Kawaharajo K, Takeuchi T

机构信息

Pharmaceutical Research Center, Meiji Seika Kaisha Ltd.

出版信息

Gan To Kagaku Ryoho. 1990 Apr;17(4 Pt 1):633-8.

PMID:2108612

Abstract

The combined effects of pirarubicin (THP) and various antitumor drugs on HeLa S3 human uterine cervix carcinoma and K562 human myelocytic leukemia cells were determined by enhancement of their cytotoxic activities. The combination of 0.15 microgram/ml THP with cisplatin (CDDP), mitomycin C (MMC), peplomycin (PEP), 5-fluorouracil (5-FU), methotrexate (MTX), enocitabine (BH-AC) or etoposide showed synergistic effects on HeLa S3 cells. Also, the combination of 0.01 microgram/ml THP with CDDP, BH-AC or etoposide showed synergistic effects on K562 cells. Especially, the combined effects of THP with MMC or MTX were remarkable, and the combination under almost all concentrations of MMC or MTX showed synergistic effects on HeLa S3 cells. On the other hand, the combination of adriamycin (ADM) with MMC or MTX did not show such a remarkable effects on HeLa S3 cells.

摘要

通过增强细胞毒性活性，测定了吡柔比星（THP）与各种抗肿瘤药物联合作用于HeLa S3人子宫颈癌细胞和K562人髓细胞白血病细胞的效果。0.15微克/毫升的THP与顺铂（CDDP）、丝裂霉素C（MMC）、培洛霉素（PEP）、5-氟尿嘧啶（5-FU）、甲氨蝶呤（MTX）、阿糖胞苷（BH-AC）或依托泊苷联合使用时，对HeLa S3细胞显示出协同作用。此外，0.01微克/毫升的THP与CDDP、BH-AC或依托泊苷联合使用时，对K562细胞也显示出协同作用。特别是，THP与MMC或MTX的联合作用显著，几乎所有浓度的MMC或MTX与THP联合使用时，对HeLa S3细胞均显示出协同作用。另一方面，阿霉素（ADM）与MMC或MTX联合使用时，对HeLa S3细胞并未显示出如此显著的效果。