Tonini G, Rosini R, Teppa A, Aulenti V, Kalantary F, Tosana M, Bianchi D, Zorzi F
Urologia. 2008 Oct-Dec;75(4):245-8.
Although most prostate carcinomas belong to the conventional acinar type, unusual variants have been reported. The adenoid cystic/basal cell carcinoma of the prostate is a rare tumor with distinctive histopathologic features. There are quite few publications in the literature concerning the diagnosis, treatment, and prognosis of this neoplasm. METHODS. A 71-year-old man had an increased PSA value (5.11 ng/dL); the prostatic biopsy examination was positive for adenoid cystic/basal cell carcinoma. For this reason we proceeded with radical prostatectomy. The histology examination showed an acinar conventional carcinoma and adenoid cystic/basal cell carcinoma. At eight months the patient did not show any recurrence. CONCLUSIONS. Various histologic and immunohistochemical features are helpful in recognizing the adenoid cystic/basal cell carcinoma of the prostate. Clinically, the only difference from a conventional adenocarcinoma is that the PSA value is usually normal or only slightly increased. This tumor has a biological potential that can result in metastases in some cases; the current treatment consists primarily in the surgical resection. A close, long-term follow-up is strongly recommended.
虽然大多数前列腺癌属于传统的腺泡型，但也有不寻常的变异型被报道。前列腺腺样囊性/基底细胞癌是一种具有独特组织病理学特征的罕见肿瘤。关于这种肿瘤的诊断、治疗和预后，文献中的报道相当少。方法：一名71岁男性前列腺特异性抗原（PSA）值升高（5.11 ng/dL）；前列腺活检检查显示腺样囊性/基底细胞癌阳性。因此，我们对其进行了根治性前列腺切除术。组织学检查显示为腺泡型传统癌和腺样囊性/基底细胞癌。八个月时，患者未出现任何复发。结论：各种组织学和免疫组化特征有助于识别前列腺腺样囊性/基底细胞癌。临床上，与传统腺癌的唯一区别在于PSA值通常正常或仅略有升高。这种肿瘤具有一定的生物学潜能，在某些情况下可导致转移；目前的治疗主要是手术切除。强烈建议进行密切的长期随访。
