Chemistry Department, Faculty of Science (Girls Sections), King Saud University, Riyadh, KSA.
Phytother Res. 2011 Jun;25(6):803-8. doi: 10.1002/ptr.3333. Epub 2010 Nov 17.
Coffee is a commonly consumed beverage. The purpose of this study was to determine the effect of the four coffee types on blood pressure (BP). The caffeine percentage was tested on one cup (250 mL) of each type of coffee (Arabian, Turkish, American and an instant coffee preparation) using two methods. 65 adult male rats and 400 healthy human volunteers were used in this study. Normotensive rats were treated orally with a single dose of normal saline with varying types of coffee. Normotensive and mildly hypertensive human volunteers were administered a cup (250 mL) of any type of coffee separately. Tail cuff and a strain-gauge plethysmograph were used to measure the systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) of the rats, and volunteers, respectively before and 0.5, 1.0, 1.5, and 2 h post administration. The mean arterial pressure (MAP) was calculated mathematically using SBP and DBP. The alkaloidal percentage of different types of coffee showed the presence variable contents and amount of active materials. The study showed that Arabian, Turkish, American and instant coffee all have the potential to cause a BP lowering effect. Variable antimicrobial activities were recorded for the different types of coffee when tested bacteria.
咖啡是一种常见的饮品。本研究旨在确定四种咖啡类型对血压（BP）的影响。使用两种方法测试了一杯（250 毫升）每种咖啡（阿拉伯咖啡、土耳其咖啡、美式咖啡和速溶咖啡）的咖啡因含量。本研究使用了 65 只成年雄性大鼠和 400 名健康的人类志愿者。正常血压大鼠经口给予不同类型的咖啡的生理盐水单一剂量。正常血压和轻度高血压的志愿者分别饮用一杯（250 毫升）任何类型的咖啡。尾套和应变计体积描记器用于测量大鼠的收缩压（SBP）、舒张压（DBP）和心率（HR），以及志愿者在给药前和给药后 0.5、1.0、1.5 和 2 小时的收缩压和舒张压。平均动脉压（MAP）通过 SBP 和 DBP 数学计算得出。不同类型咖啡的生物碱百分比显示出存在不同含量和数量的活性物质。研究表明，阿拉伯咖啡、土耳其咖啡、美式咖啡和速溶咖啡都有可能降低血压。当测试细菌时，不同类型的咖啡记录了不同的抗菌活性。
