Gorbunov A A, Gan'shina T S, Mirzoian R S
Eksp Klin Farmakol. 2010 Sep;73(9):13-6.
Experiments on rats showed that meta-chlorophenylpiperazine, as well as serotonin, decreases cerebral blood flow registered in internal carotid artery of narcotized animals. Therefore, this agonist of postsynaptic 5HT(2B/2C) receptors can be used for directed search of new antimigraine drugs. Tropoxin (10 mg/kg) substantially reduces constrictor reactions of cerebral blood vessels induced by meta-chlorophenylpiperazine. The effect was observed during both prophylaxis and treatment of the model disorder with this drug.
对大鼠的实验表明，间氯苯哌嗪以及血清素会降低麻醉动物颈内动脉记录到的脑血流量。因此，这种突触后5HT(2B/2C)受体激动剂可用于定向寻找新的抗偏头痛药物。托普oxin（10毫克/千克）可显著降低间氯苯哌嗪引起的脑血管收缩反应。在用这种药物预防和治疗模型疾病期间均观察到了该效果。
