Gan'shina T S, Gorbunov A A, Gnezdilova A V, Kurdiumov I N, Avdiunina N I, Piatin B M, Mirzoian R S
Eksp Klin Farmakol. 2011;74(8):17-22.
Experiments on rats showed that 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate increases cerebral blood flow in the system of carotid arteries both in intact animals and under conditions of global transient ischemia. In combination with tropoxin, 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate enhances the blood flow in the inner carotid artery of intact rats and the local blood flow under conditions of global transient ischemia. A combination of 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate and tropoxin increases baseline cerebral blood flow and decreases the constrictor reaction of cerebral blood vessels to 5HT(2B/2C) receptor agonist meta-chlorophenylpiperazine.
对大鼠的实验表明，2-乙基-6-甲基-3-羟基吡啶半琥珀酸酯在完整动物以及全脑短暂性缺血条件下，均可增加颈动脉系统的脑血流量。与托普西汀联合使用时，2-乙基-6-甲基-3-羟基吡啶半琥珀酸酯可增强完整大鼠颈内动脉的血流量以及全脑短暂性缺血条件下的局部血流量。2-乙基-6-甲基-3-羟基吡啶半琥珀酸酯与托普西汀联合使用可增加脑血流量基线，并降低脑血管对5HT(2B/2C)受体激动剂间氯苯哌嗪的收缩反应。
