Pavić Ivana, Marusić Zlatko, Mijić August, Balicević Drinko, Kruslin Bozo, Tomas Davor
Ljudevit Jurak University Department of Pathology, Sestre milosrdnice University Hospital, Zagreb, Croatia.
Acta Clin Croat. 2010 Jun;49(2):159-62.
The morphological spectrum of gallbladder carcinoma is broad and variable. Most of these tumors are tubular adenocarcinomas. There are some tumors with unusual morphology that may be difficult to classify due to their rarity. One of such tumors is the signet-ring cell carcinoma, which is a highly aggressive, mucin producing variant of gallbladder adenocarcinoma predominantly or exclusively composed of signet-ring cells. Histologically, these tumors are similar to their counterparts in other organs such as stomach, colon and breast, and should not be misinterpreted as metastatic carcinoma from one of these primary sites. The literature about this variant of carcinoma is sparse and little is known about it. We found only three cases of signet-ring cell carcinoma of the gallbladder previously reported. We present the case of an 86-year-old woman with signet-ring cell carcinoma of the gallbladder and discuss the potential diagnostic dilemmas
胆囊癌的形态学谱广泛且多样。这些肿瘤大多为管状腺癌。有一些形态异常的肿瘤，因其罕见可能难以分类。其中一种肿瘤是印戒细胞癌，它是胆囊腺癌的一种具有高度侵袭性、产生黏液的变体，主要或仅由印戒细胞组成。在组织学上，这些肿瘤与胃、结肠和乳腺等其他器官的同类肿瘤相似，不应被误诊为来自这些原发部位之一的转移性癌。关于这种癌变体的文献稀少，人们对其了解甚少。我们之前仅发现3例胆囊印戒细胞癌的报道。我们报告一例86岁女性胆囊印戒细胞癌病例，并讨论潜在的诊断难题
