Michal M, Chlumska A, Mukensnabl P
Medical Faculty, Charles University Pilsen, Czech Republic.
Pathol Res Pract. 1998;194(3):197-200. doi: 10.1016/S0344-0338(98)80023-X.
We describe three cases of benign signet-ring cell aggregates in the colon associated with pseudomembranous colitis, adenomatous polyp of the colon and ulcerated mucosa of the gallbladder excised for gallstones. In all cases, we found loose, benign signet-ring cell aggregates overlying the ulcerated mucosa surface, simulating signet ring-cell carcinoma. The most important sign of the benign signet-ring cell aggregates is that they are always confined to the surface of the mucosa of the intestine or gallbladder mucosa or crypts of the intestinal epithelium. In no case did we see an invasion of these cells into the lamina propria of the mucosa. In all cases, the benign signet-ring cell aggregates were immunohistochemically positive with antibodies to cytokeratins. The occurrence of benign signet-ring cell aggregates is a rare and very misleading diagnostic pitfall which must be differentiated from signet-ring cell carcinoma of the colon and gallbladder.
我们描述了三例结肠中与假膜性结肠炎、结肠腺瘤性息肉以及因胆结石而切除的胆囊溃疡黏膜相关的良性印戒细胞聚集体。在所有病例中，我们发现疏松的良性印戒细胞聚集体覆盖在溃疡黏膜表面，类似印戒细胞癌。良性印戒细胞聚集体最重要的特征是它们始终局限于肠道或胆囊黏膜表面或肠上皮隐窝内。在所有病例中，我们均未观察到这些细胞侵入黏膜固有层。在所有病例中，良性印戒细胞聚集体经细胞角蛋白抗体免疫组化检测呈阳性。良性印戒细胞聚集体的出现是一种罕见且极易造成误诊的诊断陷阱，必须与结肠和胆囊的印戒细胞癌相鉴别。
