School of Chemical and Physical Sciences, Victoria University of Wellington, P.O. Box 600, Wellington, New Zealand.
J Nat Prod. 2011 Jan 28;74(1):69-73. doi: 10.1021/np100710c. Epub 2010 Nov 18.
Examination of the New Zealand sponge Raspailia agminata resulted in the isolation of five members of a novel family of glycolipids, agminosides A-E (1-5). These large and complex molecules contain up to six partially acetylated glucose residues. The chromatographic separation of these compounds was a challenge due to the similarity of the congeners and their lack of a chromophore. MS-guided isolation followed by extensive NMR analysis and chemical derivatization eventually led to the purification and identification of 1-5.
对新西兰海绵 RaspiAia agminata 的检查导致了五种新型糖脂家族成员的分离，即 agminosides A-E（1-5）。这些大而复杂的分子含有多达六个部分乙酰化的葡萄糖残基。由于同系物的相似性及其缺乏发色团，这些化合物的色谱分离是一个挑战。通过 MS 引导的分离，然后进行广泛的 NMR 分析和化学衍生化，最终实现了 1-5 的纯化和鉴定。
